I have 3 versions of FME on my machine, 32 bit 2018 and 2019 and 64 bit 2018, installed in separate directories.
There are a couple of oddities I've experienced when changing FME options,
1) In FME 2019 I removed the Run workspace button to keep only the Rerun entire workspace button which has resulted in the loss of the run workspace button in 2018
2) If i try and set my preferred python interpreter in 2019, the settings are not saved. If I set it in 2018 they are saved, but I don't have the option to choose python 3.7+, only 3.6+, I can change in the workspace (if i remember)